Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses
نویسندگان
چکیده
منابع مشابه
Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses.
The TLRs 7, 8, and 9 stimulate innate immune responses upon recognizing pathogen nucleic acids. U-rich RNA sequences were recently discovered that stimulate human TLR7/8-mediated or murine TLR7-mediated immune effects. In this study we identified single-stranded RNA sequences containing defined sequence motifs that either preferentially activate human TLR8-mediated as opposed to TLR7- or TLR7/8...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2008
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.180.6.3729